Check Out the Process & Advantages of Preimplantation Genetic Diagnosis

Preimplantation Genetic Diagnosis is a technique that allows couples with a particular hereditary disease in their families to avoid passing it to their children. The process conducted by Genetic Tests Scottsdale AZ help prospective parents prevent the birth of a child with severe genetic disease. The procedure for PGD is similar to in vitro fertilization (IVF), with an additional step to check if the embryo is affected by a severe genetic disease.

What is preimplantation genetic testing (PGT)?

Embryos can be tested for abnormal chromosomes before they transfer to the uterus. It is called preimplantation genetic testing, or PGT. The Fertility Clinic Arizona focuses on infertility treatments, including IVF – In Vitro Fertilization. It is performed in a laboratory, using in vitro fertilization (IVF). To learn more about IVF, see the fact sheet titled ASRM in vitro fertilization (IVF). One or new cells from each embryo guide for genetic testing. Genetically healthy embryos transfer to the uterus, where you can attach to the lining and produce a pregnancy.

How can genetic tests be performed?

Embryo cells can be tested for a gene which can produce a specific disease. It will show whether an embryo is healthy (without infection) or affected (has the disease). It will also show whether the fetus is carrying the disease, but unaffected by it. A natural carrier is someone who can transmit the virus to their children, but not personally have any signs of the disease.

A karyotype is another genetic test that can check chromosomes. It is performed during pregnancy, either through chorionic villus sampling or amniocentesis. This test shows whether the fetus has more or less the usual 46 chromosomes.

Having too many or too few chromosomes can cause disorders such as Down syndrome or trisomy 13. This test can also search chromosomes out of order, called translocations, which can cause problems with growth or function.

What is Preimplantation Genetic Diagnosis (PGD)?

PGD involves testing before an embryo implants for a specific procedure, known genetic disorder. PGD uses for embryos unaffected by the disease can be returned to the uterus.

How genetic testing is performed?

The techniques are continually evolving and changing to be more accurate, more comfortable to perform and give more information. New technologies that include microarrays and sequencing of the genome are the most common methods of genetic testing.

Keep an Eye on the Classic Treatment Cycle for PGD:

Step 1: Stimulation of the ovaries

To create embryos for genetic testing, the ovaries must artificially stimulate the use of hormones to produce multiple eggs at the same time.

Step 2: Collection of eggs from the ovaries

At the appropriate time, the eggs are removed in the course of a surgical procedure known as egg retrieval. Once the eggs extract, they inspected to determine who are mature and healthy.

Step 3: Insemination/injection of sperm

Fertilization during PGD is carried out through:

In Vitro Fertilization (IVF): sperm and eggs are placed together in a culture plate to allow fertilization to occur.

Intracytoplasmic sperm injection (ICSI) a single sperm is injected into the center of an egg. This technique is used for conditions caused by a single defective gene.

Step 4: Fertilization

The morning after injection/insemination of sperm, the embryologist scrutinizes each egg to see if fertilization has occurred.

Step 5: Embryo biopsy

The fertilized eggs were successfully grown in the laboratory for 5-6 days when the embryo forms what is called a blastocyst of about 100-150 cells. This step carries out a trophectoderm biopsy.

This technique is highly specialized and can only be carried out by embryologists who have an exclusive license from the Human Fertilization and Embryology Authority (HFEA).

Step 6: Embryo Testing

The cells are tested to see if the embryo that was removed contains the genetic abnormality causing condition.

Step 7: Embryo Transfer

Only those embryos that do not have the specific genetic condition that was tested for transplanted into the uterus of the woman. Typically, a fetus is transferred to the uterus at any time to avoid the possibility of multiple births.

Any other suitable unaffected embryos will be frozen for later use.

Those embryos that are affected by hereditary disease allow lost, or couples asked if they would consider letting these embryos donated for research and training.

Step 8: Pregnancy Test

Twelve days after embryo transfer, the woman a pregnancy test is given. A positive pregnancy test by an embryo is implanted.

Who should have PGD or PGS?

PGD is for someone who has or is a carrier of a genetic disorder known. PGS may be endorsed for someone with frequent miscarriage, someone with multiple failed fertility treatments, or somebody who is older or whose ovaries do not work as well as expected. Some couples may also choose to PGS for personal reasons.

Anyone interested in PGD or PGS should consult with a fertility specialist for the procedure and alternatives can be discussed.

If you have opted for in vitro fertilization, you should know about a technique called preimplantation genetic diagnosis, or PGD. PGD allows us to test a cell from an embryo to detect genetic defects so you can decide whether to implant that embryo.

Let’s look at the advantages of this procedure:

Genetic Tests Scottsdale AZ benefit three groups of patients:

Patients with infertility problems (PGT-A)

Patients with a karyotype alteration (PGT-SR)

Patients with hereditary diseases (PGT-M)

With the help of PGD tests, more than a hundred different genetic disorders may be detected

It is allowed to see the potential problems in the embryo so you can decide whether to continue the pregnancy

By discovering aneuploidy, PGD shows the probability of involuntary abortion and implantation failure and thus allows for more successful IVF.

It also allowed the detection of sex couples to help balance their families. Still, as people began to abuse it, and the government declared illegal sex detection, doctors in many countries stopped offering it.


The Fertility Clinic Arizona aims to support the birth of healthy children. Advances in assisted reproductive technologies and genetic analyzes have led to the introduction of preimplantation genetic diagnosis (PGD) for embryos.